** RESULTS **
- High-penetrance genes - BRCA1, BRCA2, PTEN, TP53 - responsible for inherited syndromes
- Moderate-penetrance genes - CHEK2, ATM, BRIP1, PALB2, RAD51C - associated with moderate BC risk
- Low-penetrance alleles - common alleles - associated with slightly increased or decreased risk of BC
- Current clinical practice - high-penetrance genes - widely used
- Future prospect - all familial breast cancer genes - to be included in genetic test
- Research need - clinical management - of moderate and low-risk variants